Advanced age results in a diminished endothelial glycocalyx
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چکیده
منابع مشابه
The endothelial glycocalyx
Once thought to be a structure of small size and uncertain significance, the endothelial glycocalyx is now known to be an important regulator of endothelial function. Studies of the systemic vasculature have demonstrated that the glycocalyx forms a substantial in vivo endothelial surface layer (ESL) critical to inflammation, barrier function, and mechanotransduction. The pulmonary ESL is signif...
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On the outer surface of a human cell there is a dense layer of complex carbohydrates called glycocalyx, also referred to as glycans or the sugar coating on the cell surface, which is composed of a complex array of oligosaccharide and polysaccharide glucose chains that are covalently bonded to proteoglycans and lipids bound to the cell membrane surface. Studies of an intact endothelial glycocaly...
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The evidence shows that endothelial glycocalyx exerts an important role in inflammation and atherosclerosis. We previously demonstrated that hydrodynamic force such as shear stress induces the remodeling of the major component of glycocalyx including glypican-1 with attached heparan sulfate, and that sphingosine-1-phosphate (S1P) protects the glycocalyx against syndecan-1 ectodomain shedding an...
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P. Mason McClatchey, Michal Schafer, Kendall S. Hunter, Jane E. B. Reusch 5 6 7 Division of Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, 8 Colorado USA 9 10 Department of Medicine, Denver VA Medical Center, Denver, Colorado USA 11 12 Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, 13 Colorado USA 14 15 Division of Cardiology, Depar...
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Myocardial tissue edema attributable to increased microvascular fluid loss contributes to cardiac dysfunction after myocardial ischemia, cardiopulmonary bypass, hypertension, and sepsis. Recent studies suggest that carbohydrate structures on the luminal surface of microvascular endothelium are essential to prevent tissue edema. We carefully preserved these structures for visualization with elec...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2018
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00104.2018